Uniformity in the nonsynonymous substitution rates of embryonic beta-globin genes of several vertebrate species.

Abstract excerpt

The nucleotide substitution rate in structural portions of the embryonic beta-globin genes of placental mammals is lower than that for the adult beta-globin genes. This difference occurs entirely within the class of substitutions that result in nonsynonymous (replacement) differences between these genes, and therefore represents a constraint on the structure of the mammalian embryonic beta-globin proteins...

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