Article
Alloreactive lymphoid infiltrates in human heart transplants. Loss of class II-directed cytotoxicity more than 3 months after transplantation.
Human immunology - 1 Jan 1991
Ouwehand A J, Vaessen L M, Baan C C, Jutte N H, Balk A H, Essed C E, Bos E, Claas F H, Weimar W
Abstract excerpt
From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All cultures tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant. A significantly higher proportion of CD8-dominated cultures was found among cultures from biopsies without myocytolysis. In the first 3 months post transplant 57% of cultures showed...
Topics
- Antigens, Differentiation, T-Lymphocyte
- CD4 Antigens
- CD8 Antigens
- Cells, Cultured
- Cytotoxicity, Immunologic
- Graft Rejection
- HLA-D Antigens
- Heart Transplantation
- Humans
- Phenotype