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Article

Donor-specific cellular immune response against human cardiac valve allografts.

The Journal of thoracic and cardiovascular surgery - 1 Aug 1996

Hoekstra F, Knoop C, Vaessen L, Wassenaar C, Jutte N, Bos E, Bogers A, Weimar W

Abstract excerpt

We studied the presence of donor-specific T lymphocytes in explanted human cardiac valve allografts in vivo. From five of seven explants we propagated lymphocyte cultures in an interleukin-2 conditioned medium. Phenotyping revealed the presence of T-cell receptors in more than 95% of the lymphocytes obtained in each culture. Donor-specific cytotoxicity was demonstrated in three patients with known HLA status of...

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Identifiers

PMID: 8751491
DOI: 10.1016/S0022-5223(96)70250-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Donor-specific cellular immune response against human cardiac valve allografts.PMID 8751491Read ↗

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Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve diseaseSemantic proximity Read ↗

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