Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.

Developmental cell - 10 Mar 2014

Pusapati Ganesh V, Hughes Casey E, Dorn Karolin V, Zhang Dapeng, Sugianto Priscilla, Aravind L, Rohatgi Rajat

Abstract excerpt

The Hedgehog (Hh) pathway depends on primary cilia in vertebrates, but the signaling machinery within cilia remains incompletely defined. We report the identification of a complex between two ciliary proteins, EFCAB7 and IQCE, which positively regulates the Hh pathway. The EFCAB7-IQCE module anchors the EVC-EVC2 complex in a signaling microdomain at the base of cilia. EVC and EVC2 genes are mutated in Ellis van...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, Affinity
Share to Cilia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Kruppel-Like Transcription Factors

Share to NIH 3T3 Cells

Share to Smoothened Receptor

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Share to Zinc Finger Protein Gli2

Source

Open in PubMed Open full text

Identifiers

PMID: 24582806
DOI: 10.1016/j.devcel.2014.01.021
PMCID: PMC4027042

Genes

EFCAB7
EVC2
EVC
IQCE
GLI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.PMID 24582806Read ↗

Role of primary cilia and Hedgehog signaling in craniofacial features of Ellis-van Creveld syndrome.Semantic proximity Read ↗

Ellis-Van Creveld Syndrome: Clinical and Molecular Analysis of 50 Individuals.Semantic proximity Read ↗

Ellis-van Creveld syndrome and Weyers acrodental dysostosis are caused by cilia-mediated diminished response to hedgehog ligands.Semantic proximity Read ↗

Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleusSemantic proximity Read ↗

Ciliary disorder of the skeletonSemantic proximity Read ↗

Dental Anomalies in Ciliopathies: Lessons from Patients with BBS2, BBS7, and EVC2 Mutations.Semantic proximity Read ↗

C2cd3 is required for cilia formation and Hedgehog signaling in mouse.Semantic proximity Read ↗

A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stabilitySemantic proximity Read ↗

CCB79 is a primate-specific cilium initiation factor essential to maintain neural progenitor diversity in developing brain tissueSemantic proximity Read ↗

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.Semantic proximity Read ↗

Cauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndrome.Semantic proximity Read ↗

Truncation and microdeletion of EVC/EVC2 with missense mutation of EFCAB7 in Ellis-van Creveld syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.