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Article

Mutational derivatives of PhiC31 integrase with increased efficiency and specificity.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jan 2009

Keravala Annahita, Lee Solomon, Thyagarajan Bhaskar, Olivares Eric C, Gabrovsky Vanessa E, Woodard Lauren E, Calos Michele P

Abstract excerpt

phiC31 integrase is a sequence-specific phage recombinase that can recombine two short DNA sequences called attB and attP. The enzyme can also promote genomic integration of plasmids carrying attB into native mammalian sequences having partial identity to attP. To increase the efficiency of integ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19002165
DOI: 10.1038/mt.2008.241
PMCID: PMC2834998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19002165-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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