Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of amyloid beta on capacitive calcium entry in neural 2a cells.

Brain research bulletin - 16 Mar 2009

Niu Ying, Su Zuqi, Zhao Chang, Song Bo, Zhang Xiufang, Zhao Nanming, Shen Xun, Gong Yandao

Abstract excerpt

We studied the direct role of amyloid beta (Abeta) in regulating capacitive calcium entry (CCE), an important refilling mechanism for depleted intracellular calcium stores. For the first time, we found that Abeta can potentiate CCE. Neural 2a cells stably expressing Swedish mutant APP (APPswe), which can secrete large amounts of Abeta, have stronger CCE than its wild-type controls. Either reducing the Abeta in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Calcium

Share to Dipeptides

Share to Intracellular Fluid

Share to Neurons

Share to Peptide Fragments

Source

Identifiers

PMID: 19000747
DOI: 10.1016/j.brainresbull.2008.10.003

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of amyloid beta on capacitive calcium entry in neural 2a cells.PMID 19000747Read ↗

Dysregulation of Intracellular Calcium Signaling in Alzheimer's DiseaseSemantic proximity Read ↗

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein.Semantic proximity Read ↗

Effects of Amyloid-β Peptides on Voltage-Gated L-Type CaV1.2 and CaV1.3 Ca2+ ChannelsSemantic proximity Read ↗

Intracellular calcium signalling in Alzheimer’s diseaseSemantic proximity Read ↗

Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation.Semantic proximity Read ↗

Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.Semantic proximity Read ↗

The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.Semantic proximity Read ↗

Familial Alzheimer's disease-linked presenilin-1 mutation M146V affects store-operated calcium entry: does gain look like loss?Semantic proximity Read ↗

The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores.Semantic proximity Read ↗

APPswe mutation increases the frequency of spontaneous Ca2+-oscillations in rat hippocampal neurons.Semantic proximity Read ↗

FAD mutations in amyloid precursor protein do not directly perturb intracellular calcium homeostasis.Semantic proximity Read ↗

2-Aminoethoxydiphenyl Borate Potentiates CRAC Current by Directly Dilating the Pore of Open Orai1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.