Article
Inhibition of mutagenicity in Salmonella typhimurium and skin tumor initiating and tumor promoting activities in SENCAR mice by glycyrrhetinic acid: comparison of 18 alpha- and 18 beta-stereoisomers.
Carcinogenesis - 1 Feb 1991
Wang Z Y, Agarwal R, Zhou Z C, Bickers D R, Mukhtar H
Abstract excerpt
Licorice has been used as medicine and as sweetening agent in food products. The major water-soluble constituent of licorice is glycyrrhizin (GL), an oleanane triterpenoide, which is known to be partly hydrolyzed by glucuronidase to its aglycone glycyrrhetinic acid (GA) which exists in 18 alpha (...
Topics
- Animals
- Female
- Glycyrrhetinic Acid
- Lipoxygenase
- Mice
- Mutation
- Ornithine Decarboxylase
- Oxygenases
- Salmonella typhimurium
- Skin Neoplasms
- Stereoisomerism