Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.

The Journal of biological chemistry - 16 Jan 2009

Nakayama Masaaki, Hisatsune Junzo, Yamasaki Eiki, Isomoto Hajime, Kurazono Hisao, Hatakeyama Masanori, Azuma Takeshi, Yamaoka Yoshio, Yahiro Kinnosuke, Moss Joel, Hirayama Toshiya

Abstract excerpt

Helicobacter pylori VacA toxin contributes to the pathogenesis and severity of gastric injury. We found that incubation of AZ-521 cells with VacA resulted in phosphorylation of protein kinase B (Akt) and glycogen synthase kinase-3beta (GSK3beta) through a PI3K-dependent pathway. Following phosphorylation and inhibition of GSK3beta,beta-catenin was released from a GSK3beta/beta-catenin complex, with subsequent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cyclin D1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to Phospholipase C beta

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18996844
DOI: 10.1074/jbc.M806981200
PMCID: PMC2615499

Genes

NPPB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.PMID 18996844Read ↗

Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1)Semantic proximity Read ↗

Expression of CEACAM1 or CEACAM5 in AZ-521 cells restores the type IV secretion deficiency for translocation of CagA byHelicobacter pyloriSemantic proximity Read ↗

<i>Helicobacter pylori</i> Vacuolating Cytotoxin Inhibits T Lymphocyte ActivationSemantic proximity Read ↗

Role of Connexin 43 in Helicobacter pylori VacA-Induced Cell DeathSemantic proximity Read ↗

Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation.Semantic proximity Read ↗

PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins.Semantic proximity Read ↗

β-Catenin/Wnt Signaling Regulates Expression of the Membrane Type 3 Matrix Metalloproteinase in Gastric CancerSemantic proximity Read ↗

Helicobacter pylori VacA Disrupts Apical Membrane-Cytoskeletal Interactions in Gastric Parietal CellsSemantic proximity Read ↗

Green tea polyphenol EGCG suppresses Wnt/β-catenin signaling by promoting GSK-3β- and PP2A-independent β-catenin phosphorylation/degradation.Semantic proximity Read ↗

Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase.Semantic proximity Read ↗

Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.