Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha 1-antitrypsin deficiency: pathogenesis and treatment.

Hospital practice (Office ed.) - 15 Feb 1991

Crystal R G

Abstract excerpt

Inherited defects of the gene coding for a serum protein that protects alveolar walls from proteolysis constitute one cause of emphysema, with or without liver disease. The deficiency can be reversed with intravenous administration of the antiprotease, keeping serum levels above the minimum needed for lung protection.

Topics

Alleles
Cholestasis
Deficiency Diseases
Exons
Female
Humans
Male
Neutrophils
Pancreatic Elastase
Phenotype
Pulmonary Emphysema
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1899256
DOI: 10.1080/21548331.1991.11704145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1899256-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha 1-antitrypsin deficiency: pathogenesis and treatment.PMID 1899256Read ↗

Alpha one antitrypsin deficiency: from gene to treatment.Semantic proximity Read ↗

Alpha-1 antitrypsin deficiency: pathogenesis, clinical presentation, diagnosis, and treatment.Semantic proximity Read ↗

Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy.Semantic proximity Read ↗

Alpha-1-antitrypsin deficiency: biochemistry and clinical manifestations.Semantic proximity Read ↗

[Alpha 1-protease inhibitor deficiency. Diagnosis, follow-up and therapy options].Semantic proximity Read ↗

Historical role of alpha-1-antitrypsin deficiency in respiratory and hepatic complications.Semantic proximity Read ↗

Recommendations for the diagnosis and treatment of alpha-1 antitrypsin deficiency.Semantic proximity Read ↗

A Review of α1-Antitrypsin DeficiencySemantic proximity Read ↗

Current status of alpha-1-antitrypsin replacement therapy: recommendations for the management of patients with severe hereditary deficiency. Ad Hoc Committee on Alpha-1-Antitrypsin Replacement Therapy of the Standards Committee, Canadian Thoracic Society.Semantic proximity Read ↗

Alpha1-antitrypsin review.Semantic proximity Read ↗

Alpha-1-antitrypsin deficiency: Genetic variations, clinical manifestations and therapeutic interventions.Semantic proximity Read ↗

alpha1-Antitrypsin deficiency . 6: new and emerging treatments for alpha1-antitrypsin deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.