LMP1 strain variants: biological and molecular properties.

doi:10.1128/JVI.00135-06

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Article

LMP1 strain variants: biological and molecular properties.

Journal of virology - 1 Jul 2006

Mainou Bernardo A, Raab-Traub Nancy

Abstract excerpt

The ubiquitous herpesvirus Epstein-Barr virus (EBV) is linked to the development of several malignancies, including nasopharyngeal carcinoma. Latent membrane protein 1 (LMP1) is considered the EBV oncogene as it is necessary for EBV-induced transformation of B lymphocytes and is able to transform Rat-1 fibroblasts. LMP1 can activate a wide array of signaling pathways, including phosphatidylinositol 3-kinase...

Topics

Animals
Carcinoma
Cell Adhesion
Cell Line
Cell Transformation, Viral
Epstein-Barr Virus Infections
Fibroblasts
Genetic Variation
Hemolysis
Herpesvirus 4, Human
Humans
NF-kappa B
Nasopharyngeal Neoplasms
Oncogene Proteins, Viral
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt
Rats
Signal Transduction

Source

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Identifiers

PMID: 16775333
DOI: 10.1128/JVI.00135-06
PMCID: PMC1488979

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