Article
E2Fs mediate a fundamental cell-cycle deregulation in high-grade serous ovarian carcinomas.
The Journal of pathology - 1 Jan 2009
De Meyer T, Bijsmans I T G W, Van de Vijver K K, Bekaert S, Oosting J, Van Criekinge W, van Engeland M, Sieben N L G
Abstract excerpt
Several studies described a role for the E2F/Rb pathway in ovarian serous carcinomas (SCAs). Since E2F/Rb pathway deregulation is a general hallmark of human cancer, it remains unclear whether this deregulation is of particular importance in SCAs or whether it reflects a common oncological feature. Here, we have clarified this issue by the examination of microarray expression profiles of SCAs and particularly by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.