Galanin preproprotein is associated with elevated plasma triglycerides.

doi:10.1161/ATVBAHA.108.178533

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Article

Galanin preproprotein is associated with elevated plasma triglycerides.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2009

Plaisier Christopher L, Kyttälä Mira, Weissglas-Volkov Daphna, Sinsheimer Janet S, Huertas-Vazquez Adriana, Riba Laura, Ramírez-Jiménez Salvador, de Bruin Tjerk W A, Tusié-Luna Teresa, Aouizerat Bradley E, Pullinger Clive R, Malloy Mary J, Kane John P, Cruz-Bautista Ivette, Herrera Miguel F, Aguilar-Salinas Carlos, Kuusisto Johanna, Laakso Markku, Taskinen Marja-Riitta, van der Kallen Carla J H, Pajukanta Päivi

Abstract excerpt

OBJECTIVE: There is increasing physiological evidence in rodents connecting the neuropeptide galanin to triglyceride (TG) levels. We hypothesized that variation in the galanin preproprotein (GAL) gene may contribute to hypertriglyceridemia (HTG) in humans. METHODS AND RESULTS: We investigated GAL as a TG candidate gene by genotyping 4 tagSNPs in Dutch, Finnish, and Mexican familial combined hyperlipidemia (FCHL)...

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PMID: 18988886
DOI: 10.1161/ATVBAHA.108.178533
PMCID: PMC2650822

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