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Article

A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).

The Biochemical journal - 15 Feb 2009

Rónai Zsolt, Witt Heiko, Rickards Olga, Destro-Bisol Giovanni, Bradbury Andrew R M, Sahin-Tóth Miklós

Abstract excerpt

Human pancreatic trypsinogens undergo post-translational sulfation on Tyr(154), catalysed by the Golgi-resident enzyme tyrosylprotein sulfotransferase 2. Sequence alignments suggest that the sulfation of Tyr(154) is facilitated by a unique sequence context which is characteristically found in primate trypsinogens. In the search for genetic variants that might alter this sulfation motif, we identified a single...

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Source

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Identifiers

PMID: 18986305
DOI: 10.1042/BJ20081848
PMCID: PMC2700036

Genes

PRSS2
PRSS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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