Article
A second uniquely human mutation affecting sialic acid biology.
The Journal of biological chemistry - 26 Oct 2001
Angata T, Varki N M, Varki A
Abstract excerpt
Siglecs are immunoglobulin superfamily member lectins that selectively recognize different types and linkages of sialic acids, which are major components of cell surface and secreted glycoconjugates. We report here a human Siglec-like molecule (Siglec-L1) that lacks a conserved arginine residue known to be essential for optimal sialic acid recognition by previously known Siglecs. Loss of the arginine from an...
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