Article
Mitochondrial uptake of bridged bis-methylpyridinium aldoximes and induction of the "petite" phenotype in yeast.
Biochemical and biophysical research communications - 16 Sept 1991
Dodin G, Averbeck D, Demerseman P, Nocentini S, Dupont J
Abstract excerpt
The 3,3'-[omega,omega'-alkanediylbis(oxy)]bis[2- (hydroxyimino)methyl]-1-methylpyridinium derivatives bearing a linking chain of 4, 5 and 6 methylene groups are accumulated in mitochondria with increasing efficiency under the effect of the electrical potential. Accumulation does not take place with derivatives carrying a 2 and 3 methylene-long linking chain. The uptake process is saturable. The efficiency of the...
Topics
- DNA Damage
- DNA, Mitochondrial
- Hydrocarbons
- Kinetics
- Membrane Potentials
- Mitochondria
- Oxygen Consumption
- Phenotype
- Pyridinium Compounds
- Saccharomyces cerevisiae