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Article

Induction of petite mutants in yeast Saccharomyces cerevisiae by the anticancer drug dequalinium.

Mutation research - 2 May 2005

Schneider-Berlin Kristen R, Bonilla Tonya D, Rowe Thomas C

Abstract excerpt

Dequalinium (DEQ), a drug with both antimicrobial and anticancer activity, induced the formation of petite (respiration-deficient) mutants in the yeast Saccharomyces cerevisiae. DEQ was found to be approximately 50-fold more potent than ethidium bromide (EB) at inducing petites. Analysis of the DEQ-induced petite mutants indicated a complete loss of mitochondrial DNA (<1 copy/cell). Prior to the loss of mtDNA,...

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Identifiers

PMID: 15790492
DOI: 10.1016/j.mrfmmm.2004.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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