Article
The metal-coordinated Casiopeína IIIEa induces the petite-like phenotype in Saccharomyces cerevisiae.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Dec 2011
López-Rodríguez Angélica, Cárabez-Trejo Alfonso, Rosas-Sánchez Fernando, Mejía Carmen, Ruiz-Azuara Lena, Miledi Ricardo, Martínez-Torres Ataúlfo
Abstract excerpt
The Casiopeínas® are mixed chelate copper (II) complexes and promising antineoplastics agents against cancer cells and tumors in vitro and in vivo. However, the action mode of these compounds is poorly characterized. In this work the effect of the antineoplastic Casiopeína IIIEa on the metabolism and ultrastructure of the yeast Saccharomyces cerevisiae was investigated. Exposure of cells growing in rich or in...
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