Article
Streptococcus mutans SMU.623c codes for a functional, metal-dependent polysaccharide deacetylase that modulates interactions with salivary agglutinin.
Journal of bacteriology - 1 Jan 2009
Deng Dong Mei, Urch Jonathan E, ten Cate Jacob M, Rao Vincenzo A, van Aalten Daan M F, Crielaard Wim
Abstract excerpt
The genome sequence of the oral pathogen Streptococcus mutans predicts the presence of two putative polysaccharide deacetylases. The first, designated PgdA in this paper, shows homology to the catalytic domains of peptidoglycan deacetylases from Streptococcus pneumoniae and Listeria monocytogenes, which are both thought to be involved in the bacterial defense mechanism against human mucosal lysozyme and are part...
Topics
- Agglutinins
- Amidohydrolases
- Bacterial Proteins
- Carbohydrate Sequence
- Cell Adhesion
- Chitin
- Chromosomes, Bacterial
- DNA, Bacterial
- Gene Knockout Techniques
- Genetic Predisposition to Disease
- Metals
- Muramidase
- Oligosaccharides