Article
Lincomycin, rational selection of high producing strain and improved fermentation by amino acids supplementation.
Bioprocess and biosystems engineering - 1 Jun 2009
Ye Ruifang, Wang Qian, Zhou Xiaofang
Abstract excerpt
Based on the report that the introduction of the biosynthetic precursor of lincomycin, propylproline, could increase the production of lincomycin (Bruce et al. in US Patent 3,753,859, 1973), a mutant strain pro10-20, with resistance of feedback suppression of proline (an analog of propylproline)...
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