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Developing Novel Oncolytic Adenoviruses through Bioselection

28 Jan 2003

Abstract excerpt

Mutants of human adenovirus 5 (Ad5) with enhanced oncolytic activity were isolated by using a procedure termed bioselection. Two mutants, ONYX-201 and ONYX-203, were plaque purified from a pool of randomly mutagenized Ad5 that was repeatedly passaged in the human colorectal cancer cell line HT29, and they were subsequently characterized. ONYX-201 and ONYX-203 replicated more rapidly in HT29 cells than wild-type...

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PMID: 12552003
DOI: 10.1128/jvi.77.4.2640-2650.2003

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