Article
Short-term activation induces multifunctional dendritic cells that generate potent antitumor T-cell responses in vivo.
Cancer immunology, immunotherapy : CII - 1 Jun 2009
Wurzenberger Cornelia, Koelzer Viktor H, Schreiber Susanne, Anz David, Vollmar Angelika M, Schnurr Max, Endres Stefan, Bourquin Carole
Abstract excerpt
Dendritic cell (DC) vaccines have emerged as a promising strategy to induce antitumoral cytotoxic T cells for the immunotherapy of cancer. The maturation state of DC is of critical importance for the success of vaccination, but the most effective mode of maturation is still a matter of debate. Whereas immature DC carry the risk of inducing tolerance, extensive stimulation of DC may lead to DC unresponsiveness and...
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