Clinical and genetic characteristics of hereditary pancreatitis in Europe.

doi:10.1016/s1542-3565(04)00013-8

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Article

Clinical and genetic characteristics of hereditary pancreatitis in Europe.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2004

Howes Nathan, Lerch Markus M, Greenhalf William, Stocken Deborah D, Ellis Ian, Simon Peter, Truninger Kaspar, Ammann Rudi, Cavallini Giorgio, Charnley Richard M, Uomo Generoso, Delhaye Miriam, Spicak Julius, Drumm Brendan, Jansen Jan, Mountford Roger, Whitcomb David C, Neoptolemos John P

Abstract excerpt

BACKGROUND & AIMS: Hereditary pancreatitis is an autosomal dominant disease that is mostly caused by cationic trypsinogen (PRSS1) gene mutations. The aim was to determine phenotype-genotype correlations of families in Europe. METHODS: Analysis of data obtained by the European Registry of Hereditary Pancreatitis and Pancreatic Cancer was undertaken using multilevel proportional hazards modelling. RESULTS: There...

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PMID: 15017610
DOI: 10.1016/s1542-3565(04)00013-8

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PRSS1

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