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Classification of PRSS1 variants responsible for chronic pancreatitis: An expert perspective from the Franco-Chinese GREPAN study group.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Aug 2023

Masson Emmanuelle, Zou Wen-Bin, Pu Na, Rebours Vinciane, Génin Emmanuelle, Wu Hao, Lin Jin-Huan, Wang Yuan-Chen, Li Zhao-Shen, Cooper David N, Férec Claude, Liao Zhuan, Chen Jian-Min

Abstract excerpt

BACKGROUND: PRSS1 was the first reported chronic pancreatitis (CP) gene. The existence of both gain-of-function (GoF) and gain-of-proteotoxicity (GoP) pathological PRSS1 variants, together with the fact that PRSS1 variants have been identified in CP subtypes spanning the range from monogenic to multifactorial, has made the classification of PRSS1 variants very challenging. METHODS: All currently reported PRSS1...

Topics

Pancreatitis, Chronic
Trypsin
China
Gene Frequency
Mutation
France
East Asian People
Humans
European People
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Trypsinogen

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PMID: 37581535
DOI: 10.1016/j.pan.2023.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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