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Article

Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2009

Keophiphath Mayoura, Achard Vincent, Henegar Corneliu, Rouault Christine, Clément Karine, Lacasa Danièle

Abstract excerpt

White adipose tissue (WAT) in obese humans is characterized by macrophage accumulation the effects of which on WAT biology are not fully understood. We previously demonstrated that macrophage-secreted factors impair preadipocyte differentiation and induce inflammation, and we described the excessive fibrotic deposition in WAT from obese individuals. Microarray analysis revealed significant overexpression of...

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Identifiers

PMID: 18945811
DOI: 10.1210/me.2008-0183
PMCID: PMC5419324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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