[Effects of virus mutations caused by passages on vaccinal immunogenicity].

Abstract excerpt

The live attenuated viral vaccines are developed by adapting viruses in the different culture conditions or in the different hosts through several passages. Success of adaptations is based on the viral nature that viruses mutate easily. Once the vaccine strain is established, it should be maintained stably. Since the property that viral genome mutates easily is a survival strategy of viruses, it is inevitable for...

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