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Article

Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells.

Journal of lipid research - 1 Mar 2009

Vargas Noelle B, Brewer Brandy Y, Rogers Terry B, Wilson Gerald M

Abstract excerpt

LDL is the most abundant cholesterol transport vehicle in plasma and a major prognostic indicator of atherosclerosis. Hepatic LDL receptors limit circulating LDL levels, since cholesterol internalized by the liver can be excreted. As such, mechanisms regulating LDL receptor expression in liver cells are appealing targets for cholesterol-lowering therapeutic strategies. Activation of HepG2 cells with phorbol...

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Share to Extracellular Signal-Regulated MAP Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18936517
DOI: 10.1194/jlr.M800316-JLR200
PMCID: PMC2638102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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