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Article

Regulated release of ERdj3 from unfolded proteins by BiP.

The EMBO journal - 5 Nov 2008

Jin Yi, Awad Walid, Petrova Kseniya, Hendershot Linda M

Abstract excerpt

DnaJ proteins often bind to unfolded substrates and recruit their Hsp70 partners. This induces a conformational change in the Hsp70 that stabilizes its binding to substrate. By some unknown mechanism, the DnaJ protein is released. We examined the requirements for the release of ERdj3, a mammalian ER DnaJ, from substrates and found that BiP promoted the release of ERdj3 only in the presence of ATP. Mutations in...

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Share to Adenosine Triphosphate
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Share to Endoplasmic Reticulum Chaperone BiP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18923428
DOI: 10.1038/emboj.2008.207
PMCID: PMC2580786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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