Article
Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3.
The EMBO journal - 5 Nov 2008
Petrova Kseniya, Oyadomari Seiichi, Hendershot Linda M, Ron David
Abstract excerpt
P58/DNAJc3 defends cells against endoplasmic reticulum (ER) stress. Most P58 molecules are translocated into the ER lumen, and here we report selective and stable binding to misfolded proteins by P58's TPR-containing N-terminal domain. In vitro, too, P58 binds selectively to a model misfolded protein and challenge of that complex with physiological concentrations of the ER lumenal Hsp70-type chaperone BiP...
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