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Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability

15 Oct 2008

Abstract excerpt

Radiation-induced genomic instability, in which the progeny of irradiated cells display a high frequency of nonclonal genomic damage, occurs at a frequency inconsistent with mutation. We investigated the mechanism of this nontargeted effect in human mammary epithelial cells (HMEC) exposed to low doses of radiation. We identified a centrosome-associated expression signature in irradiated HMEC and show here that...

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PMID: 18922902
DOI: 10.1158/0008-5472.can-08-1212

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