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Article

The zinc RING finger of bovine herpesvirus 1-encoded bICP0 protein is crucial for viral replication and virulence.

Journal of virology - 1 Dec 2008

Saira Kazima, Chowdhury Shafiqul, Gaudreault Natasha, da Silva Leticia, Henderson Gail, Doster Alan, Jones Clinton

Abstract excerpt

Bovine herpesvirus 1 (BHV-1) infected cell protein 0 (bICP0) stimulates productive infection, in part by activating viral gene expression. The C(3)HC(4) zinc RING finger of bICP0 is crucial for activating viral transcription and productive infection. In this study, we used a bacterial artificial chromosome containing a wild-type (wt) virulent BHV-1 strain to generate a single amino acid mutation in the C(3)HC(4)...

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Source

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Identifiers

PMID: 18842710
DOI: 10.1128/JVI.01348-08
PMCID: PMC2593318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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