Article
Study of immunogenicity and virulence of bovine herpesvirus 1 mutants deficient in the UL49 homolog, UL49.5 homolog and dUTPase genes in cattle.
Vaccine - 1 Jul 1997
Liang X, Chow B, Babiuk L A
Abstract excerpt
We previously reported that the bovine herpesvirus 1 (BHV 1) gene homologous to herpes simplex virus gene UL49 is dispensable; nevertheless, a mutant with the UL49 homolog (UL49 h) gene deletion exhibited significantly impaired growth in cell culture. To further evaluate the role of the UL49 h in virus infectivity in the natural host of BHV 1, the pathogenesis of the UL49 h negative mutant was studied in cattle....
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