Article
Study of immunogenicity and virulence of bovine herpesvirus 1 mutants deficient in the UL49 homolog, UL49.5 homolog and dUTPase genes in cattle.
Vaccine - 1 Jul 1997
Liang X, Chow B, Babiuk L A
Abstract excerpt
We previously reported that the bovine herpesvirus 1 (BHV 1) gene homologous to herpes simplex virus gene UL49 is dispensable; nevertheless, a mutant with the UL49 homolog (UL49 h) gene deletion exhibited significantly impaired growth in cell culture. To further evaluate the role of the UL49 h in...
Topics
- Administration, Intranasal
- Animals
- Antibodies, Viral
- Cattle
- Genes, Viral
- Herpesvirus 1, Bovine
- Immunization
- Injections, Intramuscular
- Mutation
- Neutralization Tests
- Pyrophosphatases
- Time Factors
- Viral Envelope Proteins
- Viral Structural Proteins
- Viral Vaccines
- Virulence
- Virus Replication