Bovine herpesvirus type 1 (BHV-1) mutant lacking U(L)49.5 luminal domain residues 30-32 and cytoplasmic tail residues 80-96 induces more rapid onset of virus neutralizing antibody and cellular immune responses in calves than the wild-type strain Cooper.

doi:10.1016/j.vetimm.2012.04.015

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Article

Bovine herpesvirus type 1 (BHV-1) mutant lacking U(L)49.5 luminal domain residues 30-32 and cytoplasmic tail residues 80-96 induces more rapid onset of virus neutralizing antibody and cellular immune responses in calves than the wild-type strain Cooper.

Veterinary immunology and immunopathology - 30 Jun 2012

Wei Huiyong, He Junyun, Paulsen Daniel B, Chowdhury Shafiqul I

Abstract excerpt

Bovine herpesvirus type 1 (BHV-1) envelope protein U(L)49.5 inhibits transporter associated with antigen processing (TAP) and down-regulates cell-surface expression of major histocompatibility complex (MHC) class I molecules to promote immune evasion. Earlier, we have constructed a BHV-1U(L)49.5Δ30-32 CT-null virus and determined that in the infected cells, TAP inhibition and MHC-I down regulation properties of...

Topics

Amino Acid Sequence
Animals
Antibodies, Neutralizing
Antibodies, Viral
CD8-Positive T-Lymphocytes
Cattle
Cattle Diseases
Herpesviridae Infections
Herpesvirus 1, Bovine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunity, Cellular

Molecular Sequence Data

Mutant Proteins

Mutation

Protein Structure, Tertiary

Sequence Deletion

Viral Envelope Proteins

Viral Vaccines

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 22578851
DOI: 10.1016/j.vetimm.2012.04.015

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