Article
[Search for Fanconi anemia/BRCA pathway defects in lymphoma cell lines].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Oct 2008
Xiao Hui, Zhang Kejian, Xia Bing
Abstract excerpt
OBJECTIVE: To investigate the possible relationship between defects in the FA/BRCA pathway of genomic stability and potential pathogenesis of T and B cell lymphoma. METHODS: Nineteen cell lines derived from diverse subtypes of lymphoma for possible FA pathway defects were screened. RESULTS: No defect in FANCD2 ubiquitination was observed. However, the FANCN protein was absent in cell lines HT and Sudhl4. This...
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