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Article

Association of SNP in exon 1 of HBS1L with hemoglobin F level in beta0-thalassemia/hemoglobin E.

International journal of hematology - 1 Nov 2008

Pandit Riyaz A, Svasti Saovaros, Sripichai Orapan, Munkongdee Thongperm, Triwitayakorn Kanokporn, Winichagoon Pranee, Fucharoen Suthat, Peerapittayamongkol Chayanon

Abstract excerpt

Increase in fetal hemoglobin (Hb F) reduces globin chain imbalance in beta-thalassemia, consequently improving symptoms. QTL mapping together with previous genome-wide association study involving approximately 110,000 gene-based SNPs in mild and severe beta(0)-thalassemia/Hb E patients revealed SNPs in HBS1L significantly associated with severity and Hb F levels. Given its potential as binding site for...

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PMID: 18839276
DOI: 10.1007/s12185-008-0167-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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