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Article

Cancer Dormancy from Mice to Man: A Review

2 Aug 2006

Abstract excerpt

In this review, we focused on our studies of cancer dormancy in a murine B cell lymphoma and human breast cancer. Lifelong dormancy was induced in syngeneic mice by prior immunization to the idiotype of the tumor cell (TC) Ig before TC challenge. The mice maintained approximately 10(6) lymphoma cells in their spleen throughout their lifetime despite replication of the TCs at a reduced rate. Recurrences occurred...

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PMID: 16929181
DOI: 10.4161/cc.5.16.2995

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