Article
[Enhancing alpha-ketoglutaric acid production in Torulopsis glabrata: increase of acetyl-CoA availability].
Wei sheng wu xue bao = Acta microbiologica Sinica - 1 Jul 2008
Liang Nan, Wang Miao, Liu Liming, Du Guocheng, Chen Jian
Abstract excerpt
OBJECTIVE: This study aimed at increasing the alpha-ketoglutaric acid production of a multi-vitamin auxotrophic yeast Torulopsis glabrata, by increasing the availability of acetyl-CoA. METHODS: For this, we expressed ACS2 encoding acetyl-CoA synthase from Saccharomyces cerevisiae in the pyruvate producer Torulopsis glabrata WSH-IP303. RESULTS: Compared with that of the parent strain, the acetyl-CoA synthase...
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