Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intracellular retention of human melanocortin-4 receptor: a molecular mechanism underlying early-onset obesity in F261S pedigree of Chinese.

Biomedical and environmental sciences : BES - 1 Aug 2008

Fang Qi-Chen, Jia Wei-Ping, Cai Shu-Bing, Shao Xin-Yu, Zhang Rong, Wang Cong-Rong, Bao Yu-Qian, Xiang Kun-San

Abstract excerpt

OBJECTIVE: To investigate how F261S mutation identified from Chinese obese patients affects the function of melanocortin 4 receptor (MC4R) and to analyze the obesity-related phenotypes in subjects carrying the F261S mutation. METHODS: F261S mutant of MC4R was generated by site-directed mutagenesis. Plasmids encoding wild-type or F261S mutant of MC4R were transfected into HEK293 and COS-7 cells to examine their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to COS Cells

Share to Obesity

Share to Pedigree

Share to Receptor, Melanocortin, Type 4

Source

Identifiers

PMID: 18837289
DOI: 10.1016/S0895-3988(08)60042-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intracellular retention of human melanocortin-4 receptor: a molecular mechanism underlying early-onset obesity in F261S pedigree of Chinese.PMID 18837289Read ↗

Identification and functional characterization of novel mutations in the melanocortin-4 receptor.Semantic proximity Read ↗

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients.Semantic proximity Read ↗

A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity.Semantic proximity Read ↗

Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults.Semantic proximity Read ↗

A Novel Loss of Function Melanocortin-4-Receptor Mutation (MC4R-F313Sfs*29) in Morbid Obesity.Semantic proximity Read ↗

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.Semantic proximity Read ↗

Functional alterations of two novel MC4R mutations found in Argentinian pediatric patients with early onset obesity.Semantic proximity Read ↗

Melanocortin 4 receptor (MC4R) gene variants in children and adolescents having familial early-onset obesity: genetic and clinical characteristics.Semantic proximity Read ↗

Clinical and Functional Characterization of Melanocortin 4 Receptor genetic variants in African American and/or Hispanic children with severe early onset obesity.Semantic proximity Read ↗

Mutations in melanocortin-4 receptor and human obesity.Semantic proximity Read ↗

The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Semantic proximity Read ↗

Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.