Article
Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor.
Nature genetics - 1 Nov 2008
Scott Richard H, Douglas Jenny, Baskcomb Linda, Huxter Nikki, Barker Karen, Hanks Sandra, Craft Alan, Gerrard Mary, Kohler Janice A, Levitt Gill A, Picton Sue, Pizer Barry, Ronghe Milind D, Williams Denise, Cook Jackie A, Pujol Pascal, Maher Eamonn R, Birch Jillian M, Stiller Charles A, Pritchard-Jones Kathy, Rahman Nazneen
Abstract excerpt
Constitutional abnormalities at the imprinted 11p15 growth regulatory region cause syndromes characterized by disordered growth, some of which include a risk of Wilms tumor. We explored their possible contribution to nonsyndromic Wilms tumor and identified constitutional 11p15 abnormalities in genomic lymphocyte DNA from 13 of 437 individuals (3%) with sporadic Wilms tumor without features of growth disorders,...
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