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Article

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans.

Science (New York, N.Y.) - 3 Oct 2008

Deng Xinzhu, Yin Xianglei, Allan Richard, Lu Diane D, Maurer Carine W, Haimovitz-Friedman Adriana, Fuks Zvi, Shaham Shai, Kolesnick Richard

Abstract excerpt

Ceramide engagement in apoptotic pathways has been a topic of controversy. To address this controversy, we tested loss-of-function (lf) mutants of conserved genes of sphingolipid metabolism in Caenorhabditis elegans. Although somatic (developmental) apoptosis was unaffected, ionizing radiation-induced apoptosis of germ cells was obliterated upon inactivation of ceramide synthase and restored upon microinjection...

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Identifiers

PMID: 18832646
DOI: 10.1126/science.1158111
PMCID: PMC2585063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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