Article
The Mhc class II DRB genotype of Macaca fascicularis does not influence infection by simian retrovirus type 2.
Tissue antigens - 1 Oct 2008
Mee E T, Murrell C K, Sauermann U, Wilkinson R C, Cutler K, North D, Heath A, Ladhani K, Almond N, Rose N J
Abstract excerpt
Simian retrovirus type 2 (SRV-2) is a natural pathogen of Macaca fascicularis. Although SRV-2 may be endemic in macaque colonies, it is not necessarily detected in all individuals suggesting differential susceptibility to SRV-2; factors contributing to this susceptibility are not fully understood. We have investigated the role of host genetic origin on virus susceptibility. We have shown that high levels of...
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