Article
Risk of venous thromboembolism and clinical manifestations in carriers of antithrombin, protein C, protein S deficiency, or activated protein C resistance: a multicenter collaborative family study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 1999
Bucciarelli P, Rosendaal F R, Tripodi A, Mannucci P M, De Stefano V, Palareti G, Finazzi G, Baudo F, Quintavalla R
Abstract excerpt
Deficiencies of antithrombin (AT), protein C (PC) or protein S (PS), and activated protein C resistance (APCR) are very well-established coagulation defects predisposing to venous thromboembolism (VTE). We performed a retrospective cohort family study to assess the risk for VTE in individuals with AT, PC, or PS deficiency, or APCR. Five hundred thirteen relatives from 9 Italian centers were selected from 233...
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