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Markers that define stemness in ESC are unable to identify the totipotent cells in human preimplantation embryos

29 Sept 2008

Abstract excerpt

BACKGROUND: During human preimplantation development, early blastomeres are believed to be totipotent. It is likely, however, that blastomeres are allocated to a specific lineage prior to any morphological differentiation. NANOG, SOX2 and SALL4 are transcription factors that play a key role in controlling stemness in embryonic stem cells (ESC) and are therefore candidate markers for developmental triggers in...

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PMID: 18824471
DOI: 10.1093/humrep/den351

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