The unique role of domain 2A of the hepatitis A virus precursor polypeptide P1-2A in viral morphogenesis.

doi:10.5483/bmbrep.2008.41.9.678

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Article

The unique role of domain 2A of the hepatitis A virus precursor polypeptide P1-2A in viral morphogenesis.

BMB reports - 30 Sept 2008

Morace Graziella, Kusov Yuri, Dzagurov Georgy, Beneduce Francesca, Gauss-Muller Verena

Abstract excerpt

The initial step during assembly of the hepatitis A virus particle is driven by domain 2A of P1-2A, which is the precursor of the structural proteins. The proteolytic removal of 2A from particulate VP1-2A by an as yet unknown host enzyme presumably terminates viral morphogenesis. Using a genetic approach, we show that a basic amino acid residue at the C-terminus of VP1 is required for efficient particle assembly...

Topics

Amino Acid Sequence
Cell Line
Hepatitis A virus
Humans
Molecular Sequence Data
Mutation
Peptide Hydrolases
Protein Precursors
Protein Structure, Tertiary
Viral Structural Proteins
Virion
Virus Assembly
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 18823593
DOI: 10.5483/bmbrep.2008.41.9.678

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