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Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells

19 Aug 2008

Abstract excerpt

Enhanced expression of human telomerase reverse transcriptase (hTERT) occurs frequently during cellular immortalization. The current study was undertaken to determine the mechanism regulating the hTERT promoter activity during cellular immortalization of human oral keratinocytes. Normal human oral keratinocytes (NHOKs) were immortalized with Bmi-1 and the E6 oncoprotein of human papillomavirus type 16 to...

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PMID: 18820283
DOI: 10.1093/carcin/bgn225

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