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Article

Human Ku70/80 Associates Physically with Telomerase through Interaction with hTERT

28 Nov 2002

Abstract excerpt

Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. Here, we analyzed the physical association of Ku with human telomerase both in vivo and in vitro. Antibodies...

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Share to Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12377759
DOI: 10.1074/jbc.m208542200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Human Ku70/80 Associates Physically with Telomerase through Interaction with hTERTPMID 12377759Read ↗

Human Ku70/80 interacts directly with hTR, the RNA component of human telomeraseSemantic proximity Read ↗

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TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human TelomeresSemantic proximity Read ↗

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The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.Semantic proximity Read ↗

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