Article
Characterization of intron-1 haplotypes of the G protein beta 4 subunit gene--association with survival and progression in patients with urothelial bladder carcinoma.
Pharmacogenetics and genomics - 1 Nov 2008
Riemann Kathrin, Struwe Henrike, Eisenhardt Andreas, Obermaier Brigitte, Schmid Kurt W, Siffert Winfried
Abstract excerpt
PURPOSE: Polymorphisms in genes encoding subunits of heterotrimeric G proteins have been repeatedly associated with various cancers. As G beta gamma signaling is presumed to be involved in proliferation and invasion processes, we analyzed genetic variations in regulatory regions of GNB4, which encodes the G beta 4 subunit, for their potential influence on cancer progression. EXPERIMENTAL DESIGN: We characterized...
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