Article
Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial.
Lancet (London, England) - 15 Nov 2008
Näntö-Salonen Kirsti, Kupila Antti, Simell Satu, Siljander Heli, Salonsaari Tiina, Hekkala Anne, Korhonen Sari, Erkkola Risto, Sipilä Jukka I, Haavisto Lotta, Siltala Marja, Tuominen Juhani, Hakalax Jari, Hyöty Heikki, Ilonen Jorma, Veijola Riitta, Simell Tuula, Knip Mikael, Simell Olli
Abstract excerpt
BACKGROUND: In mouse models of diabetes, prophylactic administration of insulin reduced incidence of the disease. We investigated whether administration of nasal insulin decreased the incidence of type 1 diabetes, in children with HLA genotypes and autoantibodies increasing the risk of the diseas...
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