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Article

Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes.

Diabetes care - 1 Jun 2011

Ryhänen Samppa J, Härkönen Taina, Siljander Heli, Näntö-Salonen Kirsti, Simell Tuula, Hyöty Heikki, Ilonen Jorma, Veijola Riitta, Simell Olli, Knip Mikael

Abstract excerpt

OBJECTIVE: Despite promising results from studies on mouse models, intranasal insulin failed to prevent or delay the development of type 1 diabetes in autoantibody-positive children with HLA-conferred disease susceptibility. To analyze whether the insulin dose was inadequate to elicit an immunomodulatory response, we compared the changes observed in insulin antibody (IA) affinity and isotypes after treatment with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

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Source

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Identifiers

PMID: 21515841
DOI: 10.2337/dc10-1449
PMCID: PMC3114329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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