Article
Functional polymorphism of the promoter region of the prostacyclin synthase gene and severity of RSV infection in hospitalized children.
Journal of medical virology - 1 Nov 2008
Hashimoto Koichi, Ishibashi Kei, Gebretsadik Tebeb, Hartert Tina V, Yamamoto Akihiro, Nakayama Tomohiro, Ohashi Kazutaka, Sakata Hiroshi, Kawasaki Yukihiko, Katayose Masahiko, Sakuma Hiroko, Suzuki Hitoshi, Hosoya Mitsuaki, Peebles Ray Stokes, Suzutani Tatsuo
Abstract excerpt
Prostaglandin I(2) (PGI(2)) protects against RSV-induced illness in mice. A variable-number tandem repeat (VNTR) polymorphism has been detected in the promoter region of the PGI(2) synthase (PGIS) gene. We sought to determine if PGI(2) concentrations or polymorphisms of the PGIS gene correlate with severity of RSV lower respiratory tract infections (LRTI) in human infants. VNTR polymorphisms were studied in 81...
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