Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer.

doi:10.1038/s41598-019-54184-0

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Article

Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer.

Scientific reports - 27 Nov 2019

Yeh I-Ju, Esakov Emily, Lathia Justin D, Miyagi Masaru, Reizes Ofer, Montano Monica M

Abstract excerpt

Epigenetic modifications are known to play critical roles in the expression of genes related to differentiation and dedifferentiation. Histone lysine demethylase KDM5B (PLU-1) catalyzes the demethylation of histone H3 on Lys 4 (H3K4), which results in the repression of gene expression. KDM5B is involved in regulation of luminal and basal cell specific gene expression in breast cancers. However, the mechanisms by...

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Identifiers

PMID: 31776402
DOI: 10.1038/s41598-019-54184-0
PMCID: PMC6881367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.